Intergalactic bounty hunter Lobo is employed to capture the Man of Steel for the rare-species-collecting Preserver, who is obsessed with keeping endangered species in captivity to protect them and prevent their extinction. Superman, the last Kryptonian, is the latest catch for his collection. Upon realizing that Lobo is the last Czarnian (having killed all the others himself), he betrays the bounty hunter and adds him to the collection as well.
Brainiac, once Krypton’s all-knowing planetary computer, comes to Earth as part of his information-gathering trek across the galaxy, and partners with Lex Luthor on the basis of giving technological progress to humanity. But, as Superman discovers, Brainiac’s intent after gathering the world’s knowledge is to destroy Earth.
Thanks to the orchestrations of Luthor, terrorist John Corben becomes Metallo, a skin-covered cyborg with a Kryptonite heart. Luthor then sets the supervillain on a quest to kill Superman, but Corben begins to question his role as Metallo.
Janitor Rudy Jones runs into an accident with nuclear waste and becomes Parasite. He feeds on the energy of others, with his number one choice being Superman. In doing so, he discovers Superman’s identity.